Ecohydrological interfaces as hot spots of ecosystem processes
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چکیده
منابع مشابه
Anatomy of hot spots in protein interfaces.
Binding of one protein to another is involved in nearly all biological functions, yet the principles governing the interaction of proteins are not fully understood. To analyze the contributions of individual amino acid residues in protein-protein binding we have compiled a database of 2325 alanine mutants for which the change in free energy of binding upon mutation to alanine has been measured ...
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We present a new database of computational hot spots in protein interfaces: HotSprint. Hot spots are residues comprising only a small fraction of interfaces yet accounting for the majority of the binding energy. HotSprint contains data for 35 776 protein interfaces among 49 512 protein interfaces extracted from the multi-chain structures in Protein Data Bank (PDB) as of February 2006. The conse...
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RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for the Cas9 scalpel.
متن کاملStructural conservation of druggable hot spots in protein-protein interfaces.
Despite the growing number of examples of small-molecule inhibitors that disrupt protein-protein interactions (PPIs), the origin of druggability of such targets is poorly understood. To identify druggable sites in protein-protein interfaces we combine computational solvent mapping, which explores the protein surface using a variety of small "probe" molecules, with a conformer generator to accou...
متن کاملPredicting Protein Interaction Sites: Binding Hot-Spots in Protein-Protein and Protein-Ligand interfaces Running Header: Binding Hot-Spots in Protein Interfaces
MOTIVATION: Protein assemblies are currently poorly represented in structural databases and their structural elucidation is a key goal in biology. Here we analyse clefts in protein surfaces, likely to correspond to binding “hot-spots”, and rank them according to sequence conservation and simple measures of physical properties including hydrophobicity, desolvation, electrostatics and van der Waa...
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ژورنال
عنوان ژورنال: Water Resources Research
سال: 2017
ISSN: 0043-1397,1944-7973
DOI: 10.1002/2016wr019516